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As body fat decreases, total aromatase activity decreases, which can shift the androgen-to-estrogen ratio
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[DOI] [PubMed] [Google Scholar] Becejac T, Cesarec V, Drmic D, et al
Notably, in mice studies, GH secretagogue receptor suppression in adipose tissues protects against obesity and insulin resistance (97), whereas IGF-I increases skeletal muscle insulin sensitivity (98)
