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The article reminds hematologists of this basic physiologic principle when considering PK activators or voxelotor, drugs that alter oxygen affinity but increase hemoglobin by a modest 1 to 2 g/dL

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PCR products were separated on 2% agarose gel by electrophoresis

M1 microglia aggravate neuronal injury via secretion of cytokines such as TNF- and IL-1, whereas M2 microglia promote tissue repair through anti-inflammatory factors (e.g., IL-10) and neurotrophic support [10]

Despite challenges in reproducibility, standardization efforts and hybrid models combining chips with neural organoids are enhancing translational predictability