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Remyelination and ageing: reversing the ravages of time

10.1111/j.1530-0277.2002.tb02436.x 225 World Health Organization (2018)

Giaever, G., Chu, A.M., Ni, L., Connelly, C., Riles, L., Veronneau, S., Dow, S., Lucau- Danila, A., Anderson, K., Andre, B., Arkin, A.P., Astromo, A., El-Bakkoury, M., Bangham, R., Benito, R., Brachat, S., Campanaro, S., Curtiss, M., Davis, K., Deutschbauer, A., Entian, K.D., Flaherty, P., Foury, F., Garnkel, D.J., Gerstein, M., Gotte, D., Guldener, U., Hegemann, J.H., Hempel, S., Herman, Z., Jaramillo, D.F., Kelly, D.E., Kelly, S.L., Kotter, P., LaBonte, D., Lamb, D.C., Lan, N., Liang, H., Liao, H., Liu, L., Luo, C., Lussier, M., Mao, R., Menard, P., Ooi, S.L., Revuelta, J.L., Roberts, C.J., Rose, M., Ross-Macdonald, P., Scherens, B., Schimmack, G., Shafer, B., Shoemaker, D.D., Sookhai-Mahadeo, S., Storms, R.K., Strathern, J.N., Valle, G., Voet, M., Volckaert, G., Wang, C.Y., Ward, T.R., Wilhelmy, J., Winzeler, E.A., Yang, Y., Yen, G., Youngman, E., Yu, K., Bussey, H., Boeke, J.D., Snyder, M., Philippsen, P., Davis, R.W

GLP-1 albumin fusions stimulate insulin secretion through a GLP-1R-dependent mechanism To test the ability of the GLP-1 albumin fusions to activate the GLP-1R in vitro, we used a human GLP-1R reporter cell assay kit, where serial dilutions of unfused GLP-1, GLP-1 WT, or GLP-1 QMP were incubated with the cells overnight (Fig