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Retatrutide is a multi-receptor agonist targeting GLP-1, GIP, and glucagon receptors , which are all involved in regulating metabolism and energy use

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doi: 10.1016/0024-3205(75)90352-5

Amino acid sensing and activation of mechanistic target of rapamycin complex 1: implications for skeletal muscle

doi: 10.2133/dmpk.dmpk-13-nt-006

This article extensively outlines the GMs precise regulation of bone metabolic homeostasis, including intestinal barrier homeostasis control, immune homeostasis, the release of metabolic products (e.g., estrogen, IGF-1, and 5-HT signaling), the endocrine system, and the neural circuitry