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Other companies, including Terns Pharmaceuticals (TERN-601), Structure Therapeutics (GSBR-1290), and Viking Therapeutics, have oral GLP-1 programs at earlier stages of development, but none has reached Phase 3 or generated the depth of clinical data available for orforglipron

Thus, further studies are needed to confirm these findings.

Adverse effects (AEs) were found only when the dose was higher than 1000 mg/kg in nonhuman primates and higher than 800 mg/kg in rats

[DOI] [PubMed] [Google Scholar] 42.McCormack MC, Nowak KC, Koch RJ

PeerJ 5 , e3933 (2017)

Potential therapeutic applications of glutathione peroxidase mimics A wide range of selenium-containing synthetic molecules that can mimic the function of GPx have been synthesized and evaluated for their activity