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For this reason, individuals with pre-existing skin disorders or impaired skin integrity should avoid prolonged exposure to topical applications or water with markedly elevated pH (72, 73)

These results underscore the promising therapeutic potential of DSIP-CBBBP in mitigating sleep-related neurological impairments, paving the way for future research into targeted treatments for such conditions

In neutrophils, high concentrations of dopamine (10 4 and 10 5 M) inhibited IL-8 mediated transendothelial migration (Sookhai et al., 2000)

Therefore, there is an urgent need to comprehensively clarify the molecular mechanisms underlying AIH and to explore novel therapeutic strategies

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In comparison to the unmodified HGII , these expectations are not supported by our results