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To investigate the effect of BDNF on hippocampal cognitive functions after global cerebral ischemia in rats, BDNF was administered continuously over 14 days via an osmotic mini-pump, intracerebroventricularly after four-vessel occlusion

Meta-analysis was conducted using a random effects model where heterogeneity was low to moderate (I 2 = 0-60%)

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64 In a randomized, double-blind pilot study that assessed the impact of adding silymarin (420 mg/day) to standard chemotherapy on the clinical response of advanced malignancies following three cycles of cisplatin-based chemotherapy, a tendency of decreased metastasis rate in the chemotherapy plus silymarin group was reported though there was no significant variance in tumor size