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In parallel, downregulation of PGC-1 and inhibition of the NRF1/TFAM pathway reduce mitochondrial DNA (mtDNA) copy number and impair biogenesis, limiting the replenishment of damaged mitochondria ( 6.2 Endoplasmic reticulum The endoplasmic reticulum (ER) is a highly specialized organelle in eukaryotic cells that performs essential physiological functions, including lipid metabolism, calcium homeostasis, and the folding and maturation of secretory and membrane proteins (Wang et al., 2018)

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For instance, MIMOSA applies machine learning to metabolic network models to identify how specific microbial metabolites interact with host cells, potentially affecting epithelial barrier integrity or immune responses

Optimality and evolutionary tuning of the expression level of a protein