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8385 Importantly, the LDL-C lowering achievable with ANGPTL3 inhibition occurs via a mechanism of action thatunlike most currently approved lipid-lowering therapies such as statins, ezetimibe, and proprotein PCSK9 inhibitorsis independent of the LDLR

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44,45 In vivo , DDD was detected in rats receiving DDT by stomach tube and not in those receiving DDT intraperitoneally, 44 suggesting probable involvement of the GI microbiota in DDT metabolism

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