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Bacterial products such as LPS, predominantly derived by gramnegative organisms, can activate microglia TLR4 [214, 215], enhancing syn uptake, oxidative stress, and cytokine productionall contributing to neurotoxicity [216, 217, 218]

doi: 10.1113/jphysiol.1997.sp021881

Pernicious AnemiaPernicious anemia is a blood disorder in which the body does not make enough red blood cells due to a lack of vitamin B12 in the blood

Rats right kidneys were dissected and washed with PBS (10 mM PO43, 137 mM NaCl, and 2.7 mM KCl

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However, very high doses aren't more effective than moderate doses for most people