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doi: 10.1038/jcbfm.2010.2

It is FDA-approved specifically for HIV-associated lipodystrophy and is not approved for general weight loss

A commenter suggested that before any measure replacement is adopted, CMS conduct a detailed comparison of the measure that would be removed and the measure that would be adopted as a replacement to ensure the replacement measure provides at least the scope and granularity of information as the measure being replaced, especially in the case where the measure domain of the proposal would be affected (such as when a claims-based measure is proposed to replace an OASIS-based measure)

C677T: G/G: typical function A/G: enzyme function decreased by ~40% A/A: enzyme function decreased by 7080% A1298C: T/T: typical function G/T: slightly decreased function G/G: enzyme function decreased by ~20% Are there other MTHFR variants that matter

Think of it like this, when you are starting a fire you need matches, wood, and paper