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Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for core targets of metformin treatment in DKD were performed using the Metascape data platform ( and the bioinformatics online tool ( Phosphorylated proteomics analysis Lysis buffer (8 M urea, 1% protease inhibitor, 1% phosphatase inhibitor, 50 M PR-619, 3 M TSA, 50 mM NAM) was added to samples from each group, and ultrasonic lysis was performed, followed by centrifugation

Less tyrosinase activity means less melanin produced, which means fewer and lighter dark spots over time

BPC-157 influences multiple signaling pathways rather than targeting any single receptor

Actin is the cellular protein that forms the cytoskeletal rails along which repair cells migrate