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doi: 10.1016/J.JCLEPRO.2020.123219 38 European Food Safety Authority (EFSA)

Genetics Severe elevations of Hcy concentration in plasma is rare and often caused by homozygous mutations in enzymes involved in its metabolism, such as MS, methylene tetrahydrofolate reductase, and CBS

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Abstract: Drug toxicity is often caused by electrophilic reactive metabolites that covalently bind to proteins

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