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Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)

and the Beijing Municipal Health Commission: Study on repair mechanism of nervous system injury [Grant No.PXM2020_026280_000002] AUTHORS CONTRIBUTIONS LI De Zhi, SCHUMACHER Michael, and LIU Song conceived and designed the experiments

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