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However, in human subjects of the Alzheimers Disease Neuroimaging Initiative (ADNI), the GRN rs5848 AD risk variant, which causes at least 1020% reduction of PGRN protein levels, has no significant effects on florbetapir PET amyloid imaging or cerebrospinal fluid (CSF) A levels, whereas it is associated with increased CSF tau levels [52], suggesting a potential effect of PGRN deficiency on tau pathology, rather than amyloid pathology

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This pathway synergizes with Pb 2+ -induced metabotropic glutamate receptor 3 (GRM3) downregulation, effectively removing the molecular brakes on post-synaptic excitation (132)

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The DSI sequence, characterized by multiple b -values along several diffusion directions, is more sensitive to white matter slow diffusion compartment 59, 60, 61, 62 (that is, intra-axonal diffusion) than classical diffusion tensor imaging and was only recently applied to schizophrenia

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[DOI] [PubMed] [Google Scholar] Chen Y., Cai J., Anders M.W., Stevens J.L., Jones D.P

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