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In cases of more advanced osteoarthritis, the use of stem cells can help to replace cells that were damaged

[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Waheed S.M., Ghosh A., Chakravarti R., Biswas A., Haque M.M., Panda K., Stuehr D.J

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Research Protocol Summary Study Protocol: 0.25 mg AOD-9604 administered intra-articularly via ultrasound guidance Frequency: Weekly injections Duration: 4-7 weeks in research studies Combination Therapy: 6 mg hyaluronic acid co-administered for enhanced effects Assessment Timeline: Significant improvements observed by 8-9 weeks Note: These protocols are from animal research and have not been validated for human use

The restoration of biomechanical properties demonstrated in animal ligament models suggests potential for improved outcomes compared to rest and splinting alone