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In chondrocytes, ferroptosis occurs primarily due to oxidative stress, iron overload, and impaired antioxidant defense mechanisms such as reduced activity of glutathione peroxidase 4 (GPX4) and the cystine/glutamate antiporter system Xc

Insulin-like growth factor I (IGF-I) replacement therapy increases albumin concentration in liver cirrhosis: results of a pilot randomized controlled clinical trial

Step 2: Reduce the primary aggravator (load, biomechanics, inflammation, sleep deficit)

Obes (Silver Spring) (2008) 16(2):4926

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