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Moreover, the overexpression of PHGDH in a mouse model resulted in resistance to erlotinib in xenografts, and the knockdown of PHGDH rescued the tumoricidal effect and restored sensitivity to erlotinib in both cell lines and xenografts (Dong et al., 2018)

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For a closer look at its structure, you can read more about What Is in Glutathione

The first step is to define the specific cell type and clinical application

Unfortunately, few randomized clinical trials investigated the different effects between machine perfusion and cold storage in deceased donor kidney transplantation (139)