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Its synthesis occurs in two phases and counts on the action of two enzymes: -glutamyl-cysteine-synthetase and glutathione-synthetase [24]
doi: 10.1615/CritRevEukaryotGeneExpr.2021037390
doi: 10.1080/08958370490439597
CTLA-4 expressed by Tregs downregulates the surface expression of CD80 and CD86 on antigen-presenting cells (APCs) such as dendritic cells (DCs) and B cells, thereby withdrawing CD28-mediated costimulatory signals in responder T cells [23,24,25,26]
