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The EC50 values at pH 7.5 and 8.5 were 9 and 22 times that at pH 6.0, respectively, and the coefficient of variation (CV) of the EC50 values at the three pH levels reached 104.6%

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UV shelters or down-conversion material could be used to block or convert the UV light to visible light for improved stability 97,98

The combination creates a broader regenerative environment, and the two compounds do not compete for the same receptors