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The goal is to reduce the physiological work required to neutralize and eliminate organic acids, support renal handling of metabolic waste and improve the biochemical terrain in which adenosine, homocysteine and SAH are managed

The goal is to find the highest dose you can tolerate comfortably, not to reach the maximum dose as quickly as possible

PLoS One 8: e81155 pmid:24312270 21

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These effects can often be minimised by taking CoQ10 with food or dividing the daily dose into smaller amounts taken throughout the day

These effects of Pycnogenol supplementation on blood pressure were investigated in a small RDP crossover study with eleven borderline hypertension patients (28)