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Under normoxic conditions, HIF1a is targeted for proteasomal degradation via hydroxylation of specific prolyl residues catalyzed by enzymes called prolyl hydroxylase domain proteins (PHD)
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An interaction with the dopamine system has already been noted for many known peptides (neurotensin, CCK, etc.)

One minute you are floating on air, and the next you are trapped under water, or trying to run in deep mud, or walking into your office without pants on
