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Upon ferroptosis induction, NRF2 activation leads to increased CHAC1 expression, contributing to the degradation of GSH and facilitating ferroptotic cell death

doi: 10.1210/jc.2018-02202 192 BeccutiGGuaraldiFNattaGCambriaVPrencipeNCicolinAet al

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High-performance liquid chromatography analyses demonstrated that GA was predominantly metabolized into 4-O-methyl GA in peripheral blood and urine (Shahrzad and Bitsch, 1998)