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7 This iron-dependent epigenetic regulation via CD44 is crucial as it enhances the expression of genes that sustain CSC characteristics

For experiments, S9-mix (co-factor-supplemented S9-fraction) was prepared immediately prior to use and was kept on ice until use (Ames et al

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The newly synthesized PL can then undergo the propagation step again, generating more PLOOHs and PL

When mutations or functional polymorphisms occur in these genes, the efficiency of DNA damage repair is significantly compromised, leading to an accumulation of carcinogenic mutations that heighten the risk of developing bladder cancer (Rafnar et al., 2009)