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Research suggests KPV may influence inflammatory pathways such as NF-kB and MAPK signaling and may reduce production of certain pro-inflammatory cytokines in experimental models

Clin Chem Lab Med 57:15651573 Nagamoto-Combs K, McNeal DW, Morecraft RJ, Combs CK (2007) Prolonged microgliosis in the rhesus monkey central nervous system after traumatic brain injury

doi: 10.1152/japplphysiol.00932.2006

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[DOI] [PMC free article] [PubMed] [Google Scholar] Pedre B, Barayeu U, Ezeria D, Dick TP

To make the dose-response evaluation, the available dose-response data should be employed