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Following the loss of dopamine-producing neurons, there is a subsequent degeneration of other neuronal subtypes, giving rise to symptoms unresponsive to dopamine modulation

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25(OH)D3 half-life: 0.06 (0.02) d

And coptisine exerts an anti-hepatoma effect by activating the 67 kDa laminin receptor/cGMP signal to induce the apoptosis of human hepatoma cells, and the proliferation and migration of HCC cells (Zhou et al., 2018)