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Managing DPN remains challenging due to its complex and poorly understood pathophysiology, varied clinical manifestations, and underdeveloped staging [23,174]

Thus, it is likely that some of the behavioral outcomes associated with these anxiety and depressive-like behaviors may be related to the protective effects of GHSR signaling in the VTA (Chuang et al., 2011

The analysis of marker groups is based on a minimum rectangular envelope around each marker

All other reagents were analytical-grade

125 The expression and activity of the SOP enzymes appear to be strongly related to the H 2 S levels to which the corresponding cells or tissues are exposed

On the other hand, multiple enzymes involved in serine biosynthesis, namely Psph and Phgdh as well as Activating Transcription Factor 4 (Atf4) target genes such as Asns, Psat1, Nars and Sars were more expressed in IECs from Stard7 IEC mice (Fig