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GLP-1 and GIP analogs are also used as injectable therapies for DM

Each peptide plays a unique role in this therapy: Tesamorelin (TES) stimulates growth hormone production, reducing visceral fat and improving metabolic health

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However, some cardiovascular risk markers, including C-reactive protein (CRP) and high molecular weight adiponectin, do not seem to normalize despite the restoration of physiologic cortisol concentrations, suggesting that exposure to excess GCs has lasting adverse effects on cardiovascular risk

10.1016/j.ijhydene.2014.10.129 71 KamangerpourA.Ashraf-KhorassaniM.TaylorL.McnairH.ChoridaL