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Keywords : Apolipoproteins, Potential communicators of lipoproteins, The pathogenesis of early atherosclerosis, Treatment of early atherosclerosis Atherosclerosis is considered to be a chronic inflammatory disease of abnormal accumulation of cholesterol, mainly in the large and medium arteries, leading to high morbidity and mortality worldwide 1-3

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It is a 13-amino-acid chain held in a specific three-dimensional shape by hydrogen bonds and hydrophobic interactions, and that shape determines whether it binds to melanocortin-1 receptors or does nothing at all

Lancet 2021;398:26276