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In comparison, patients with SCO2 mutations tend to have earlier-onset symptoms that progress more rapidly, including hypertrophic cardiomyopathy, dystonia, and seizures

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Chen X, Laurent S, Onur OA, Kleineberg NN, Fink GR, Schweitzer F, et al

While the tyrosyl phosphorylation cascade on the insulin receptor traditionally mediates the insulin signaling, emerging evidence indicates that the hormone can also initiate an alternative H 2 O 2 -dependent response via the actions of NAD(P)H oxidase (NOX) 31,32

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