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CoQ10 is also a potent anti-inflammatory agent that effectively down-regulates cytokines (i.e., TNF-, IL- 6, CRP) and could optimize viral-disrupted ACE2/RAAS system, by exerting anti-angiotensin II effects and decreasing OxS in COVID-19 patients 537,538

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Consequently, effective clearance of ROS and improvement of the intracellular oxidative stress microenvironment in NPCs are essential for alleviating IVDD