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The rationale for combining GLP-1 receptor agonists such as semaglutide with an amylin analogue such as cagrilintide is that we want to achieve the benefit of a dual formulation, explains Melanie Davies, University of Leicester, UK, and principal investigator in the REDEFINE study programme evaluating the combination therapy

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26 Studies have demonstrated that arginine and lysine amino acid substitution in peptides favorably facilitate insertion into bacteria membrane due to their positive charge interacting with bacterial membrane, while the presence of hydrophobic amino acids such as tryptophan and phenylalanine within peptide sequences are associated intensified antimicrobial activity against bacteria

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