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Although its origin is still unknown, among the main causes related to long COVID (LC) are the persistence of chronic SARS-CoV-2 infection [33, 97,98,99,100,101,102,103,104,105], autoimmunity [106,107,108,109,110,111,112,113,114,115,116], chronic inflammatory state with immune alteration [110, 117,118,119,120,121,122,123,124,125,126,127], EpsteinBarr virus reactivation [128,129,130,131,132,133,134,135,136,137,138,139,140], hypocortisolism [128, 133, 141,142,143], or microclot formation [33, 144,145,146,147,148,149]

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The IFN-I can activate the Janus kinase 1 (JAK1)/tyrosine kinase 2signal transducer and activator of transcription 1/2 (STAT1/2) pathway, promoting the formation of the STAT1/2/IRF9 complex and initiating transcription of IFN-stimulated genes (ISGs) (Fig

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But, B12 mixes can have different strengths

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MSM is found in green plants, animals, and humans and can also be obtained through supplements and topical creams

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[DOI] [PMC free article] [PubMed] [Google Scholar] 178.Harada M, Itoh H, Nakagawa O, Ogawa Y, Miyamoto Y, Kuwahara K, Ogawa E, Igaki T, Yamashita J, Masuda I, Yoshimasa T, Tanaka I, Saito Y and Nakao K

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