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In these cases, the TB-500 oral taste becomes a direct, unavoidable factor in the research protocol
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This reflex can be increased or decreased, or both, in spastic patients
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This way, the vials can remain germ-free for up to 4 weeks and can be used for multiple dosing
However, clinical translation is hindered by low oral bioavailability, limited BBB permeability, and inconsistent pharmacokinetics
