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XJB-5-131 significantly inhibits the increase of tert-butyl hydroperoxide-induced ferroptosis-driving factors (PTGS2, TFR1, and ATF3) and the accumulation of ferroptosis markers (Fe 2+ , ROS, and lipid peroxide) in chondrocytes

The EU's Scientific Committee on Consumer Safety (SCCS) said the mouse findings might point to a concern but they're hard to apply to humans since hairless mouse skin and human skin behave differently

[DOI] [PubMed] [Google Scholar] 52.Whitworth J.A., Williamson P.M., Mangos G., Kelly J.J

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Nonetheless, there are detectable changes in Tau phosphorylation and expression induced in this TBI model and they are completely unaffected by preinjury supplementation with Immunocal, suggesting that they may represent biochemical changes caused by, or in response to, the primary mechanical injury induced by TBI