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I bring this up because I've read that B12 is known to raise histamine levels, injections in particular

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Special Considerations for Off-Label Use Those seeking B12 for off-label purposes should be particularly cautious: Unknown B12 status could mask severe deficiency Underlying medical conditions might increase risk Interaction with other supplements or medications False sense of security leading to delayed medical care Risk of hiding serious underlying conditions The Critical Importance of Pre-Treatment Testing Given these potential complications, comprehensive blood testing before B12 replacement therapy is essential, regardless of intended use

Failing to account for this when switching vial sizes is one of the most common and dangerous reconstitution errors

Now that they are buying their own fluids (locally or via mail order), they're following the same protocol and injecting the new bags with the appropriate supplements