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This is accelerated by heat, light, metal ion catalysts (Cu2+, Fe3+), alkaline pH, and air exposure

Bantle JP2009Dietary fructose and metabolic syndrome and diabetes

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Neurochem Res 47:739747

Accordingly, clinical studies are afforded the ability to collect whole blood into several different anticoagulant-coated tubes, which is not typically feasible in preclinical studies

European review for medical and pharmacological sciences
