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Three active peptide compound Glutathione (Glutathione, GSH) is made up of glutamic acid, cysteine and glycine by peptide bonds condensation of three peptide compounds, chemical name called gamma-L-glutamine-L-in ammonia acyl-glycine, its structural formula is shown in figure 1

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Based on the evidence that NOX4 is highly expressed in uterine fibroid tissues [47], it can be inferred that progesterone can provide auxiliary support for E-induced NOX4 activity in fibroid cells through a similar mechanism, thereby potentially synergistically amplifying the pro-oxidative effect of E functionally