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PGAM5 removes phosphate from its target substrates which can promote mitochondrial fusion and biogenesis thereby contributing to cell survival or the result can promote mitochondrial fission and apoptosis leading to programmed cell death

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References Pinhas-Hamiel, O

10.1038/ncomms11756 [DOI] [PMC free article] [PubMed] [Google Scholar] 48.Chiou J, Zeng C, Cheng Z et al (2021) Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk