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Phenobarbital has a very long half-life

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and (4) impaired vascular metabolic regulation (e.g., reduced glucose uptake and CBF deficits)

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While the research shows promise, especially for heart failure and after heart attacks, there are concerns about a byproduct called TMAO, which might increase the risk of clogged arteries

Dialysis-associated carnitine deficit, in turn, has been linked to a number of symptoms seen in uremic patients, including fatigability, cardiomyopathy, anemia, and skeletal muscle weakness (Eknoyan et al., 2003)