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Gopal S., Mikulskis A., Gold R., et al., Evidence of Activation of the Nrf2 Pathway in Multiple Sclerosis Patients Treated With DelayedRelease Dimethyl Fumarate in the Phase 3 DEFINE and CONFIRM Studies, Multiple Sclerosis 23, no

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The reactivity of Cys with oxidants is known to be pH and environment sensitive, with this arising partly from the increased reactivity of the thiolate (RS ) over the neutral form 33 , but also from electronic and structural factors [cf

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