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However, in a randomized phase III double-blind clinical trial, tivantinib did not improve OS time in patients with Met-high advanced HCC treated with sorafenib compared with placebo (Rimassa et al., 2018) (NCT01755767)

10.1056/NEJM199704173361601 N Engl J Med

4, Table 1)

Sci Rep 10(1):13660

Imaging Tests In addition to the examination, your doctor may recommend imaging tests to help confirm a diagnosis

Among these, TNF- production by CGCs can increase senescence of mouse oocytes after ovulation, which may be the cause of oocyte quality decline (106)
