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doi: 10.1038/nri2691 45 XuLYangTWenMWenDJinCAnMet al

It is well established that a Cys deficiency decreases glutathione production, which precludes the GPX4-mediated reductive detoxification of lipid peroxides [30]

Threonine Catabolism via Threonine Dehydrogenase (non-functional in humans) An additional pathway of threonine catabolism in mammals occurs in the mitochondria and is initiated by threonine dehydrogenase (TDH

The introduction of miR-351-5p (the target of circPtpn14) was found to reverse the 5-LOX upregulation and ER stress signaling activation caused by circPtpn14 overexpression alone and to rescue the decreased cell viability, inhibition of GPX activity, and increased blood-brain barrier permeability in vitro caused by circPtpn14 Wu et al

Genome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements

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