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Genetic or breed-related causes: Certain breeds, including Border Collies, Beagles, and Giant Schnauzers, have an inherited defect in the mechanism that allows B12 to be absorbed

The supernatant was then analyzed by HPLC with a Rainin Econosphere ODS C18 column and an acetonitrile/water mobile phase containing 0.1% trifluoroacetic acid

AOD 9604 meets the first two criteria clearly

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Zheng T, Qin L, Chen B et al (2016) Association of plasma DPP4 activity with mild cognitive impairment in elderly patients with type 2 diabetes: results from the GDMD Study in China