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Description
Further studies generated pharmacokinetic profiles of intranasal vascular endothelial growth factor in rats and intranasal allopregnanolone in mice, which measured the highest drug concentrations in the trigeminal nerve, optic nerve and olfactory bulb followed by the cerebrum and hippocampus [79, 80]
If deficiency or tissue utilization concerns arise, functional markers like methylmalonic acid (MMA) and homocysteine levels may offer additional context (source: Harvard T.H
Metallothionein, a protein in which Cys comprises 30% of the amino acid residues, is induced ten-fold at 24 hr after acute EtOH administration in young rats and mice [68-70]
Certain metals were quantified by ICP-MS (Mass Spectrophotometry) in hair (g/g: Al, Hg, Ba, Ag, Sb, As, Be, Bi, Cd, Pb, Pt, Tl, Th, U, Ni, Sn, Ti) and SOD-1 and Glutathione (reduced form) levels in plasma
However, the low expression levels of recombinant proteins in cultured mammalian cells presents a challenge
Apparsundaram, V
