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Therefore, ferroptosis enhances M1-type macrophage polarization, worsens peripheral inflammation, and accelerates AS progression (Ma et al., 2022)

[DOI] [PubMed] [Google Scholar] 88.Anderson M.E

First isolated in 1977 from rabbit cerebral venous blood, DSIP is classified as amphiphilic, meaning it contains both water-attracting and water-repelling regions

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It has been shown that reprogramming HCC cells with nuclear factors such as HNF1A, HNF4A and FOXA3, can convert these cancerous cells to hepatocyte-like cells ( When using primary human hepatocytes to assess DILI, it is common to pool cells from multiple donors due to the limited number of viable hepatocytes that can be isolated from each individual (Figure 6), and importantly, we identified based on the incidence and the severity that donepezil and sitaxentan are categorized as less-DILI concern and most-DILI concern compounds, respectively (Figure 8)