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Risk of primary adrenal insufficiency in patients with celiac disease

Bhattacharjee, N

The age-related decline in mitochondrial biogenesis, impaired oxidative phosphorylation (OXPHOS), and increased reactive oxygen species (ROS) production create an energetic deficit, compromising ATP-intensive processes like protein synthesis and sarcomere maintenance ( Critically, the interplay between sarcopenia and obesity converges into a distinct clinical phenotype known as sarcopenic obesity, which represents a high-risk geriatric syndrome characterized by the co-existence of reduced muscle mass/function and excess adiposity ( Finally, ectopic fat deposition results from the inability of subcutaneous fat to expand healthily, leading to lipid spillover into muscle ( Figure 1 )

For references and more information , see the section on cardiovascular disease in the Vitamin C article

Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration

Other microbial metabolites such as lactate isomers, valerate, and branched-chain SCFAs are also present but at considerably lower concentrations [69, 70]