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Technical and biological biases in bulk transcriptomic data mining for cancer research

University of Arizona scientists found doing so lifted glutathione levels by up to 84 percent in five weeks

In hypoxic epithelial ovarian cancer, as a transcription factor of IGF-1, highly expressed ELF3-mediated secretion of IGF-1 and VEGF promoted endothelial cell proliferation, migration and tumor angiogenesis through activation of the tyrosine kinase pathway, whereas ELF3 silencing attenuated angiogenesis and tumorigenesis in a xenograft mouse model, demonstrating the pro-vascular effect of IGF-1 (39)

[DOI] [PubMed] [Google Scholar] 140.Geisler S., Mayersbach P., Becker K., Schennach H., Fuchs D., Gostner J.M

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