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Meanwhile, researchers discovered Mitochondria-targeted antioxidants (MTAXs) that can improve mitochondrial functions and antioxidant activity through the modulation of mitochondrial signaling pathways, including peroxisome proliferator-activated receptor (PPAR)-coactivator 1 (PGC-1), dynamin-related protein 1 (Drp1), mitochondrial fission protein 1 (Fis1), and Silent mating type information regulation 2 homolog 1 (SIRT-1), showing neuroprotective effects in HD

These findings indicated that GSH treatment increased GSH levels in Fabry kidney organoids, which decreased ROS and oxidative stress levels

Authors' contributions HN, MR, JJ, and CM formulated the questions and contributed substantially to the design of the project

Nevertheless, dysregulation of HIF-1 signaling axis would lead to skeletal dysplasia by interfering with cellular bioenergetics and biosynthesis (Stegen et al., 2019)

Consistent supplementation may help improve energy levels, cognitive clarity, and natural liver detoxification pathways