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As well as causing B12 deficiency, an increase in methylmalonic acid occurs, which is thought to result in loss of myelin in the peripheral nerves and, consequently, neuropathy, which may be symptomatic as early as 2 years into metformin treatment

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(2018) characterized the substrate site-targeting mechanism and selectivity profile of the 5-amino-1-methylquinolinium series in Cell Chemical Biology

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